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The Philadelphia 76ers (1-0) are favored by 3.5 points against the Cleveland Cavaliers (0-0) on Thursday, October 22, 2026 at 7 p.m. ET. The matchup airs on ESPN.
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Listen to the game on Newsradio WTAM 1100
Cavaliers vs. 76ers Predictions for Thursday
Our computer projection model for this contest expects a final tally of Cavaliers 116, 76ers 115.
- Moneyline Pick: Cavaliers (+125)
- Total Pick: Under 235.5 (computer predicts 230.9 points)
- Pick ATS: Cavaliers (+3.5)
Recent Cavaliers vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/9/2026 | Cavaliers | -13.5 | 226.5 | -877 | +592 | 115-101 CLE |
| 1/16/2026 | 76ers | -2.5 | 233 | -139 | +117 | 117-115 CLE |
| 1/14/2026 | Cavaliers | -1.5 | 236.5 | -105 | -114 | 133-107 CLE |
| 11/5/2025 | Cavaliers | -10.5 | 235.5 | -483 | +368 | 132-121 CLE |
76ers 2025-26 Betting Trends
- Philadelphia had 41 wins in 82 games against the spread last season.
- As 3.5-point favorites or more, the 76ers went 19-10 against the spread last season.
- Out of 82 Philadelphia games last season, 41 hit the over.
- The 76ers won 34 of the 46 games they were listed as the moneyline favorite last season (73.9%).
- When it played as a moneyline favorite with odds of -149 or shorter last year, Philadelphia finished with a record of 26-3 (89.7%).
Cavaliers 2025-26 Betting Trends
- Cleveland put together a 34-47-1 ATS record last year.
- The Cavaliers had an ATS record of 4-2 as underdogs of 3.5 points or more last year.
- A total of 40 of Cleveland's games last season hit the over.
- The Cavaliers were underdogs 16 times last season and won seven, or 43.8%, of those games.
- Last season, Cleveland won two of its six games when it was the underdog by at least +125 on the moneyline.
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Cavaliers vs. 76ers Injury Report
76ers
76ers:
Ariel Hukporti: Out For Season (Achilles),
Dominick Barlow: Out (Back),
Tacko Fall: Day-To-Day (Hip),
Dean Wade: Day-To-Day (Ankle)
Cavaliers
Cavaliers:
Nae'Qwan Tomlin: Out (Back)
Cavaliers vs. 76ers Game Time and TV Channel
- Game day: Thursday, October 22, 2026
- Game time: 7 p.m. ET
- TV channel: ESPN
- Location: Philadelphia, Pennsylvania
- Arena: Xfinity Mobile Arena
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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