Photo: Jess Rapfogel / Getty Images Sport / Getty Images
The Cleveland Cavaliers take the court against the New York Knicks as only 2.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 7 p.m. ET on ESPN and MSG.
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Listen to the game on ESPN New York
Cavaliers vs. Knicks Predictions for Wednesday
Our computer projection model for this matchup calls for a final result of Cavaliers 117, Knicks 113.
- Moneyline Pick: Cavaliers (-154)
- Total Pick: Over 227.5 (computer predicts 229.8 points)
- Pick ATS: Cavaliers (-2.5)
Recent Cavaliers vs. Knicks Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 4/11/2025 | Knicks | -2 | 223.5 | -149 | +125 | 108-102 CLE |
| 4/2/2025 | Cavaliers | -10.5 | 231.5 | -515 | +389 | 124-105 CLE |
| 2/21/2025 | Cavaliers | -7.5 | 241.5 | -296 | +238 | 142-105 CLE |
| 10/28/2024 | Knicks | -3 | 222.5 | -142 | +121 | 110-104 CLE |
Cavaliers 2024-25 Betting Trends
- Cleveland had 48 wins in 82 games against the spread last year.
- As 2.5-point favorites or greater, the Cavaliers went 41-29-1 against the spread last year.
- There were 50 Cleveland games (out of 82) that went over the total last year.
- The Cavaliers won 81.1% of the games last season in which they were favored on the moneyline (60-14).
- Cleveland had a record of 56-10 when it played as a moneyline favorite with odds of -154 or shorter last year (84.8%).
Knicks 2024-25 Betting Trends
- New York covered 40 times in 82 chances against the spread last year.
- Against the spread, as underdogs of 2.5 points or more, the Knicks went 5-11 last season.
- New York and its opponent combined to go over the point total 42 out of 82 times last season.
- The Knicks won four, or 23.5%, of the 17 games they played as underdogs last season.
- Last season, New York won one of its 12 games, or 8.3%, when it was the underdog by at least +129 on the moneyline.
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Cavaliers vs. Knicks Injury Report
Cavaliers
Cavaliers:
Darius Garland: Out (Toe),
Max Strus: Out (Foot),
De'Andre Hunter: Questionable (Knee)
Knicks
Knicks:
Josh Hart: Out (Back),
Mitchell Robinson: Out (Rest),
OG Anunoby: Probable (Ankle),
Karl-Anthony Towns: Questionable (Quadricep)
Cavaliers vs. Knicks Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7 p.m. ET
- TV channel: ESPN and MSG
- Location: New York City, New York
- Arena: Madison Square Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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