The No. 1 Ohio State Buckeyes (5-0) square off against a conference opponent when they visit the No. 17 Illinois Fighting Illini (5-1) on Saturday, October 11, 2025 at Memorial Stadium (Champaign, IL) in a Big Ten clash.
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Ohio State vs. Illinois Matchup Info
- Game date: Saturday, October 11, 2025
- Game time: 12 p.m. ET
- Location: Champaign, Illinois
- Venue: Memorial Stadium (Champaign, IL)
- TV channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Ohio State vs. Illinois Odds and Prediction
- Spread favorite: Buckeyes (-14.5)
- Moneyline: Buckeyes (-699), Fighting Illini (+500)
- Total: 50.5 points
- Pick ATS: Illinois (+14.5)
- Pick OU: Under (50.5)
- Prediction: Illinois 26, Ohio State 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Ohio State vs. Illinois Betting Records and Insights
- Ohio State has put together a 4-1-0 record against the spread this season.
- Illinois has put together a 5-1-0 record against the spread this year.
- The Buckeyes have been favored by 14.5 points or more three times this season, and covered the spread in two of those games.
- So far this season, two Ohio State games have hit the over.
- Illinois and its opponent have combined to go over the point total four out of six times this year.